Takemoto S, Terasaki P
Clin Transpl. 1990:497-513.
With the aid of computers, the HLA molecule for 52 specificities was cut up into peptides of 2-7 amino acids in length. From all possible peptides identified, we produced an extensive table of peptides unique to each HLA specificity. The HLA types of donors and recipients of first cadaver donor transplants were then converted to their peptides and used for matching. When compared to conventional matching, tripeptide matching was more effective in identifying patients with extremely poor outcomes. The total effectiveness of peptide matching was rather modest, although it is anticipated that this new tool, together with refined knowledge of the most immunogenic peptides, will provide a more practical method of HLA matching for allotransplantation.
在计算机的辅助下，将具有52种特异性的HLA分子切割成长度为2至7个氨基酸的肽段。从所有鉴定出的可能肽段中，我们生成了一个广泛的表格，列出了每种HLA特异性所特有的肽段。然后将首次尸体供体移植的供体和受体的HLA类型转换为它们的肽段并用于匹配。与传统匹配相比，三肽匹配在识别预后极差的患者方面更有效。肽段匹配的总体有效性相当有限，尽管预计这种新工具与对最具免疫原性的肽段的深入了解相结合，将为同种异体移植提供一种更实用的HLA匹配方法。
