Sánchez Sánchez M L, Schoendorff Ortega J, Uria Aramburu A, de Pablos Mateos I, Rubio Pérez P
Servicio de Medicina Interna I y de Medicina Nuclear, Hospital Universitario de San Carlos, Facultad de Medicina, Universidad Complutense, Madrid.
An Med Interna. 1990 Feb;7(2):71-4.
The plasmatic levels of TSH in 2 group of diabetic patients (7 decompensated and 8 decompensated, but in treatment) were measured at 9:30 and 23:30 hours. The mean glycemia levels were of 280 +/- 45 and 150 +/- 30 mg/dl (p less than 0.0005). There was no significant difference between daily TSH and nocturnal TSH in any of the groups, but there was a tendency for the nocturnal TSH to be higher in decompensated patients. There was no difference when comparing the TSH of the first group to the TSH of the 2nd group. The mean TSH N/TSH D was superior by 1 (1.36 in decompensated and 1,095 in treated patients). The correlation between glycemia and TSH D was negligible in all groups. The data suggests the tendency that the circadian rhythm of TSH in maintained in diabetes decompensation with shorter rhythm registered in treated patients. This shows a certain normality in the suprahypophysary area in charge of the rhythm and is similar to the minor liberation of TSH after TRH stimulus that other authors have described as happening in the decompensation of diabetes mellitus.
在上午9:30和晚上23:30测量了两组糖尿病患者（7例失代偿期和8例失代偿期但正在接受治疗）的血浆促甲状腺激素（TSH）水平。平均血糖水平分别为280±45和150±30mg/dl（p<0.0005）。在任何一组中，日间TSH和夜间TSH之间均无显著差异，但失代偿期患者的夜间TSH有升高趋势。比较第一组和第二组的TSH时无差异。平均TSH夜间/日间比值第一组比第二组高1（失代偿期患者为1.36，治疗患者为1.095）。在所有组中，血糖与日间TSH之间的相关性可忽略不计。数据表明，糖尿病失代偿期患者TSH的昼夜节律得以维持，而治疗患者的节律较短。这表明负责该节律的垂体上区域具有一定的正常性，这与其他作者所描述的糖尿病失代偿期促甲状腺激素释放激素（TRH）刺激后TSH释放减少的情况相似。
