Nadol'nik L I
Biomed Khim. 2010 Jul-Aug;56(4):443-56.
The review highlights the effects of acute and chronic stress on thyroid metabolism. Special attention is paid to the influence of stress and the direct effects of glucocorticoids on the thyroid status, the activities of thyrocyte iodine uptake, oxidation and organification as well as peripheral metabolism of thyroid hormones (deposition and transport of thyroid hormones, deiodinase activities in different tissues). The role of stress in the development of thyroid pathology is analysed and characteristic features of thyroid function alterations during impaired functioning of the pitiutary-adrenal system are established. The mechanisms of the stress-induced impairments in thyroid functions are of interest for further research, taking into consideration serious consequences of thyroid deficiency for the body, even in subclinical thyroid insufficiency.
该综述强调了急性和慢性应激对甲状腺代谢的影响。特别关注应激的影响以及糖皮质激素对甲状腺状态、甲状腺细胞碘摄取、氧化和有机化活性以及甲状腺激素外周代谢（甲状腺激素的沉积和转运、不同组织中的脱碘酶活性）的直接作用。分析了应激在甲状腺病理发展中的作用，并确定了垂体 - 肾上腺系统功能受损期间甲状腺功能改变的特征。考虑到甲状腺功能减退即使在亚临床甲状腺功能不全时对身体也会产生严重后果，应激诱导的甲状腺功能损害机制值得进一步研究。
