吞咽困难患者吸入辣椒素引起的咳嗽反射。
Cough reflex induced by capsaicin inhalation in patients with dysphagia.
作者信息
Imoto Yoshimasa, Kojima Akihiro, Osawa Youko, Sunaga Hiroshi, Fujieda Shigeharu
机构信息
Department of Sensory and Locomotor Medicine, University of Fukui, Japan.
出版信息
Acta Otolaryngol. 2011 Jan;131(1):96-100. doi: 10.3109/00016489.2010.516013. Epub 2010 Oct 29.
CONCLUSIONS
We conclude that the capsaicin inhalation test is useful to directly assess cough reflex and sensation around the larynx, while it indirectly reflects central nervous system function.
OBJECTIVES
To understand the state of the cough reflex before patients with dysphagia start eating.
METHODS
We studied the cough reflex by the capsaicin inhalation test in 21 patients with dysphagia and 12 healthy persons without dysphagia.
RESULTS
The control group showed a cough reflex at a capsaicin concentration of 2.61 μM (0.98-7.80), while patients with mild dysphagia did so at 7.28 μM (1.95-15.6), those with moderate dysphagia at 22.07 μM (15.6-62.5), and those with severe dysphagia at 71.75 μM (31.2-250). Control vs mild p < 0.01, control vs moderate p < 0.01, control vs severe p < 0.01, mild vs moderate p < 0.01, mild vs severe p < 0.01, moderate vs severe p < 0.05. There was a significant correlation between the grade of dysphagia and the threshold capsaicin concentration that provoked a cough reflex (ρ = -0.796, p < 0.001).
结论
我们得出结论，辣椒素吸入试验有助于直接评估咳嗽反射和喉部周围感觉，同时间接反映中枢神经系统功能。
目的
了解吞咽困难患者开始进食前咳嗽反射的状态。
方法
我们通过辣椒素吸入试验研究了21例吞咽困难患者和12例无吞咽困难的健康人的咳嗽反射。
结果
对照组在辣椒素浓度为2.61μM（0.98 - 7.80）时出现咳嗽反射，轻度吞咽困难患者在7.28μM（1.95 - 15.6）时出现，中度吞咽困难患者在22.07μM（15.6 - 62.5）时出现，重度吞咽困难患者在71.75μM（31.2 - 250）时出现。对照组与轻度组比较p < 0.01，对照组与中度组比较p < 0.01，对照组与重度组比较p < 0.01，轻度与中度组比较p < 0.01，轻度与重度组比较p < 0.01，中度与重度组比较p < 0.05。吞咽困难程度与引发咳嗽反射的辣椒素阈值浓度之间存在显著相关性（ρ = -0.796，p < 0.001）。
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