Western Australian Centre for Health and Ageing, University of Western Australia, Australia.
J Neuroinflammation. 2010 Oct 29;7:71. doi: 10.1186/1742-2094-7-71.
Vascular dysfunction and brain inflammation are thought to contribute to the pathophysiology of cerebral injury in acute stroke. However acute inflammation and vascular dysfunction may simply be markers of an acute phase response to cerebral injury, reflecting the size of the cerebral lesion. We aimed to determine if systemic markers of vascular dysfunction and inflammation are independently associated with concentrations of the astroglial protein S100B, a marker of brain injury, in participants with acute ischaemic stroke.
Fifty-seven men and women recruited within 96 hours of acute ischaemic stroke at two tertiary hospitals participated in this cross sectional observational study. Clinical, imaging (stroke lesions area measured with perfusion CT) and laboratory data were the independent variables and co-variates. The outcome variable was serum S100B concentration, analysed by multivariate regression.
High sensitivity-CRP (B = 0.41) and lesion area (B = 0.69) were independently associated with S100B concentration (R2 = 0.75, p < 0.01). Other variables with significant univariate associations with S100B concentration were not independently associated with S100B concentration in the final multivariate model.
The degree of systemic inflammation is associated with S100B concentration in acute ischaemic stroke, independent of the size of the ischaemic lesion.
血管功能障碍和脑炎症被认为是导致急性中风脑损伤的病理生理学的原因。然而，急性炎症和血管功能障碍可能只是对脑损伤的急性期反应的标志物，反映了脑损伤的大小。我们旨在确定急性缺血性中风患者中全身血管功能障碍和炎症标志物是否与星形胶质蛋白 S100B（脑损伤的标志物）浓度独立相关。
在两家三级医院急性缺血性中风发作后 96 小时内招募的 57 名男性和女性参与了这项横断面观察性研究。临床、影像学（通过灌注 CT 测量中风病灶面积）和实验室数据为自变量和协变量。因变量为血清 S100B 浓度，通过多元回归进行分析。
高敏 C 反应蛋白（B = 0.41）和病灶面积（B = 0.69）与 S100B 浓度独立相关（R2 = 0.75，p < 0.01）。与 S100B 浓度有显著单变量相关性的其他变量在最终多元模型中与 S100B 浓度无独立相关性。
全身炎症程度与急性缺血性中风中的 S100B 浓度相关，与缺血性病灶的大小无关。
