Department of Biology and Biomedical Science, Dong-A University, Busan 604-714, Korea.
BMB Rep. 2010 Oct;43(10):698-703. doi: 10.5483/BMBRep.2010.43.10.698.
In this study, we characterized two blocks of minisatellites in the 5' upstream region of the BORIS gene (BORIS-MS1, -MS2). BORIS-MS2 was found to be polymorphic; therefore, this locus could be useful as a marker for DNA fingerprinting. We assessed the association between BORIS-MS2 and breast cancer by a case-control study with 428 controls and 793 breast cancers cases. Rare alleles in the younger group (age, <40) were associated with a statistically significant increased risk of breast cancer (odds ratio, 4.84; 95% confidence interval, 1.06-22.22; and P = 0.026). A statistically significant association between the short rare alleles and cancer was identified in the younger group (8.02; 1.01-63.83; P = 0.021). Kaplan-Meier estimates showed that poor prognosis was associated with patients who contained the rare alleles. Our data suggest that the short rare alleles of BORIS-MS2 could be used to identify the risk for breast cancer in young patients.
在这项研究中，我们对 BORIS 基因（BORIS-MS1、-MS2）5'上游区域的两个微卫星块进行了特征描述。发现 BORIS-MS2 呈多态性；因此，该基因座可作为 DNA 指纹图谱的有用标记。我们通过病例对照研究，对 428 名对照和 793 名乳腺癌病例进行了 BORIS-MS2 与乳腺癌之间的相关性评估。在年轻组（年龄<40 岁）中，罕见等位基因与乳腺癌的风险显著增加相关（比值比，4.84；95%置信区间，1.06-22.22；P=0.026）。在年轻组中，短的罕见等位基因与癌症之间存在显著的关联（8.02；1.01-63.83；P=0.021）。Kaplan-Meier 估计表明，含有罕见等位基因的患者预后较差。我们的数据表明，BORIS-MS2 的短的罕见等位基因可用于识别年轻患者的乳腺癌风险。
