World Health Organization Collaborating Centre for Reference and Research on Influenza, Melbourne, Australia.
Euro Surveill. 2010 Oct 21;15(42):19692. doi: 10.2807/ese.15.42.19692-en.
Pandemic H1N1 influenza virus is of global health concern and is currently the predominant influenza virus subtype circulating in the southern hemisphere 2010 winter. The virus has changed little since it emerged in 2009, however, in this report we describe several genetically distinct changes in the pandemic H1N1 influenza virus. These variants were first detected in Singapore in early 2010 and have subsequently spread through Australia and New Zealand. At this stage, these signature changes in the haemagglutinin and neuraminidase proteins have not resulted in significant antigenic changes which might make the current vaccine less effective, but such adaptive mutations should be carefully monitored as the northern hemisphere approaches its winter influenza season.
大流行 H1N1 流感病毒引起全球关注，目前是南半球 2010 年冬季流行的主要流感病毒亚型。自 2009 年出现以来，该病毒变化不大，但在本报告中我们描述了大流行 H1N1 流感病毒的几个遗传上明显不同的变化。这些变体最早于 2010 年初在新加坡被检测到，此后已在澳大利亚和新西兰传播。在现阶段，这些血凝素和神经氨酸酶蛋白中的特征性变化尚未导致抗原性发生重大变化，从而使当前的疫苗效力降低，但随着北半球进入冬季流感季节，应密切监测这种适应性突变。
