Influenza Centre, The Gade Institute, University of Bergen, N-5021 Bergen, Norway.
Vaccine. 2010 Dec 16;29(2):266-73. doi: 10.1016/j.vaccine.2010.10.038. Epub 2010 Oct 27.
Mass vaccination was the most effective prophylaxis for protecting the population during the influenza H1N1 pandemic. We have evaluated the tolerability, immunogenicity and kinetics of the antibody response to a monovalent oil-in-water (AS03) adjuvanted human pandemic split influenza A/California/7/2009 H1N1 (3.75 μg haemagglutinin) vaccine in health care workers. Vaccination elicited a rapid and early protective level of haemagglutination inhibition antibody from 6 to 7 days post vaccination, and by 14 to 21 days post vaccination, up to 98% of vaccinees had protective antibody titres which persisted for at least 3 months in 84-92% of subjects. A rapid induction of protective antibody is important in reducing community spread of pandemic influenza and in helping maintain the integrity of the health care system during the pandemic.
大规模疫苗接种是在流感大流行期间保护人群的最有效预防措施。我们评估了在卫生保健工作者中接种单价油包水（AS03）佐剂的人用季节性流感 A/加利福尼亚/7/2009 H1N1（3.75 μg 血凝素）疫苗的耐受性、免疫原性和抗体应答动力学。疫苗接种后 6 至 7 天即可产生快速和早期的血凝抑制抗体保护水平，并且在接种后 14 至 21 天，多达 98%的疫苗接种者产生了保护性抗体滴度，在 84-92%的受试者中至少持续 3 个月。快速诱导保护性抗体对于减少大流行性流感在社区中的传播以及在大流行期间帮助维持卫生保健系统的完整性非常重要。
