Department of Rehabilitation Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Osteoarthritis Cartilage. 2011 Jan;19(1):22-8. doi: 10.1016/j.joca.2010.10.013. Epub 2010 Oct 27.
To assess the effects of joint effusion on proprioceptive status in patients with knee osteoarthritis (OA).
A single-blind, randomized, controlled clinical trial in 40 female subjects aged 50 years and over with painful knee OA. All subjects were randomly assigned to either the control or experimental group. A volume of 20 mL of normal saline was injected into the knee joint cavity of subjects in the experimental group under ultrasonographic guidance. Proprioceptive acuity was assessed by active repositioning of the lower limb using an electrogoniometer to measure knee joint position sense (JPS) under both non-weight-bearing (NWB) and weight-bearing (WB) conditions twice, with a 20-min rest interval. The experimental group performed the task twice (Test 1 and Test 2) before and within 5 min after joint infusion. The control group also performed Test 1 and Test 2 without joint infusion. The outcome of interest was the absolute angular error (AAE), ignoring the direction of the error, between the randomized target angle and the patient's reproduced angle of JPS values.
Compared with the control group, JPS was significantly compromised in the experimental group in the NWB test after joint infusion (P=0.025). However, no significant differences in the angular error were observed between Test 1 and Test 2 in the control group for the NWB or WB test or in the experimental group for the WB test after infusion (P>0.05).
This study showed that joint effusion impairs proprioceptive function in osteoarthritic knee joints.
评估膝关节骨关节炎（OA）患者关节积液对本体感觉状态的影响。
在 40 名年龄在 50 岁及以上、患有疼痛性膝关节 OA 的女性受试者中进行的单盲、随机、对照临床试验。所有受试者均随机分为对照组或实验组。实验组在超声引导下向膝关节腔内注射 20 毫升生理盐水。使用电子角度计主动重新定位下肢，在非负重（NWB）和负重（WB）条件下两次测量膝关节位置感（JPS），两次测量之间有 20 分钟的休息间隔，评估本体感觉敏锐度。实验组在关节内注射前和注射后 5 分钟内进行两次测试（测试 1 和测试 2）。对照组也在没有关节内注射的情况下进行测试 1 和测试 2。感兴趣的结果是随机目标角度和患者 JPS 值再现角度之间的绝对角度误差（AAE），忽略误差的方向。
与对照组相比，实验组在关节内注射后的 NWB 测试中 JPS 显著受损（P=0.025）。然而，在 NWB 或 WB 测试中，对照组在测试 1 和测试 2 之间，或在关节内注射后的 WB 测试中，实验组的角度误差没有显著差异（P>0.05）。
本研究表明，关节积液会损害骨关节炎膝关节的本体感觉功能。
