Matrisian L M, Bowden G T
Department of Cell Biology, Vanderbilt University, Nashville, TN 37232.
Semin Cancer Biol. 1990 Apr;1(2):107-15.
Transin is an oncogene-inducible protein which has been shown to be the rat homologue of an extracellular matrix-degrading metalloproteinase known as stromelysin. The activity of transin/stromelysin is regulated at several levels: (1) at the transcriptional level, it is positively regulated by oncogenes, tumor promoters, and certain growth factors, and is negatively regulated by several agents including glucocorticoids and transforming growth factor-beta; (2) the protease activity is produced by processing of an inactive precursor form to an active enzyme; and (3) total protease activity is modulated by activity of tissue inhibitors of metalloproteinases (TIMPs). The association of transin/stromelysin expression with tumor progression suggests that it plays an important role in cancer.
转胶酶是一种癌基因诱导蛋白，已被证明是一种称为基质溶素的细胞外基质降解金属蛋白酶的大鼠同源物。转胶酶/基质溶素的活性在多个水平受到调节：（1）在转录水平，它受到癌基因、肿瘤启动子和某些生长因子的正调控，并受到包括糖皮质激素和转化生长因子-β在内的多种因子的负调控；（2）蛋白酶活性是通过将无活性的前体形式加工成活性酶而产生的；（3）总蛋白酶活性受金属蛋白酶组织抑制剂（TIMPs）活性的调节。转胶酶/基质溶素表达与肿瘤进展的关联表明它在癌症中起重要作用。
