Ataturk University, Faculty of Medicine, Department of Pediatric Surgery, 25240, Erzurum, Turkey.
J Pediatr Surg. 2010 Nov;45(11):2154-9. doi: 10.1016/j.jpedsurg.2010.07.027.
The aim of the study was to examine whether endogenous cortisol and adrenalin have a role in the formation of stress ulcers in intact and adrenalectomized rats.
The study was composed of 4 experiments: ulcerated areas in stomachs of adrenalectomized and intact rats were measured, adrenaline (100 μg/kg) and prednisolone (5 mg/kg) were injected intraperitoneally in adrenalectomized rats, metyrapone (200 mg/kg) and metyrosine (200 mg/kg) were administered to intact rats, and metyrapone (200 mg/kg) and metyrosine (200 mg/kg) were administered orally with yohimbine (10 mg/kg) and yohimbine (10 mg/kg) alone were administered to intact rats. After 24-hour restraint stress, ulcerated areas were measured.
In the stomach of intact rats, the degree of stress ulcer was 7.25 times more severe than that noted in adrenalectomized rats. Furthermore, stress ulcers in adrenalectomized rats that received adrenaline or prednisolone only were fewer and less severe than rats receiving both adrenaline and prednisolone.
Simultaneous administration of adrenaline and prednisolone did not prevent the formation of stress ulcers. However, either of these hormones alone (adrenaline or prednisolone), in the absence of the other, repressed the formation of stress ulcers. This antiulcer activity may be related to α2-adrenergic receptor activity.
本研究旨在探讨内源性皮质醇和肾上腺素是否在完整和肾上腺切除大鼠应激性溃疡的形成中起作用。
该研究由 4 个实验组成：测量肾上腺切除和完整大鼠胃的溃疡面积，向肾上腺切除大鼠腹腔内注射肾上腺素（100μg/kg）和泼尼松龙（5mg/kg），给予完整大鼠美替拉酮（200mg/kg）和美替酪氨酸（200mg/kg），并单独给予完整大鼠美替拉酮（200mg/kg）和美替酪氨酸（200mg/kg），同时给予育亨宾（10mg/kg）。在 24 小时束缚应激后，测量溃疡面积。
在完整大鼠的胃中，应激性溃疡的严重程度是肾上腺切除大鼠的 7.25 倍。此外，仅接受肾上腺素或泼尼松龙的肾上腺切除大鼠的应激性溃疡比同时接受肾上腺素和泼尼松龙的大鼠更少且更轻微。
同时给予肾上腺素和泼尼松龙不能预防应激性溃疡的形成。然而，这些激素中的任何一种（肾上腺素或泼尼松龙）单独使用（不与另一种激素一起使用）都会抑制应激性溃疡的形成。这种抗溃疡活性可能与α2-肾上腺素能受体活性有关。
