Division of Allergy, Immunology and Infectious Diseases, New Brunswick, NJ, USA.
J Pediatr Nurs. 2010 Dec;25(6):500-4. doi: 10.1016/j.pedn.2009.07.002. Epub 2009 Aug 21.
The evaluation of HIV treatment adherence is essential to manage the development of resistant mutations, treatment failure, and disease progression in patients with HIV-1 infection; however, none of the commonly used measures of treatment adherence have been found to be accurate. The objective of this study was to evaluate three treatment adherence measures (caregiver reports, pharmacy refill, and appointment maintenance data) in association with viral load suppression in pediatric patients with HIV-1 infection. Although viral suppression was not found to be significantly associated with adherence defined by any single measure, treatment adherence could be predicted if all three measures were in agreement.
评估 HIV 治疗依从性对于管理 HIV-1 感染患者耐药突变的发展、治疗失败和疾病进展至关重要；然而，目前尚未发现常用的治疗依从性评估方法是准确的。本研究旨在评估三种治疗依从性评估方法（照料者报告、药物配给记录和预约维持数据）与 HIV-1 感染儿科患者病毒载量抑制之间的关联。尽管病毒抑制与任何单一评估方法定义的依从性无显著关联，但如果所有三种方法一致，那么可以预测治疗依从性。
