Nishibe S, Carpenter G
Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, TN 37232-0146.
Semin Cancer Biol. 1990 Aug;1(4):285-92.
The significance of tyrosine phosphorylation in cell growth and transformation has been addressed. While the details of how tyrosine kinases actually function in mitogenic signal transduction is not fully understood, recent evidence suggests that phosphoinositide metabolism may have a significant role in growth factor signal transduction. Interestingly, one of phosphatidylinositol-specific phospholipase C isozymes is an excellent substrate for growth factor receptor tyrosine kinases. In this review, the current understanding of growth factor-mediated phosphoinositide metabolism and tyrosine phosphorylation of phospholipase C, is discussed.
酪氨酸磷酸化在细胞生长和转化中的意义已得到探讨。虽然酪氨酸激酶在促有丝分裂信号转导中实际发挥作用的细节尚未完全明了，但最近的证据表明磷脂酰肌醇代谢可能在生长因子信号转导中起重要作用。有趣的是，磷脂酰肌醇特异性磷脂酶C同工酶之一是生长因子受体酪氨酸激酶的优良底物。在这篇综述中，讨论了目前对生长因子介导的磷脂酰肌醇代谢以及磷脂酶C酪氨酸磷酸化的理解。
