Peyrière M-P, Roth P, Combourieu D, Vavasseur C, Bouvier R, Guibaud L, Gaucherand P
Service d'obstétrique, centre pluridisciplinaire de diagnostic prénatal, hôpital Femme-Mère-Enfant, 69500 Bron, France.
Gynecol Obstet Fertil. 2010 Nov;38(11):663-7. doi: 10.1016/j.gyobfe.2010.09.008. Epub 2010 Oct 28.
The purpose of this study is to describe the diagnosis, the care and the prognosis of the fetuses with an antenataly diagnosed megacystis.
Six year retrospective study about 46 cases of megacystis (26 diagnosed during 1st trimester; 14 during 2nd trimester; 9 during 3rd trimester) referred in the prenatal fetal medicine unit of the Femme-Mère-Enfant hospital in Lyon (France).
The main aetiology is urethral occlusion, particularly for megacystis discovered during the 1st and the 2nd trimesters. Twenty-two terminations of pregnancy were performed (47.8%) and 6 pregnancies arrested spontaneously (13%). Eighteen children were born alive, but 2 died in neonatal period. Finally, 16 children survived (34.8%). Chromosomal abnormalities are frequent (22%).
Antenatal discovery of a megacystis is a complex situation, and often of poor fetal prognosis. It requires a multidisciplinary approach to allow the concerned couple to be determined on the best care of this pregnancy.
本研究旨在描述产前诊断为巨膀胱胎儿的诊断、护理及预后情况。
对法国里昂母婴医院产前胎儿医学科转诊的46例巨膀胱病例进行了为期六年的回顾性研究（26例在孕早期诊断；14例在孕中期诊断；9例在孕晚期诊断）。
主要病因是尿道梗阻，尤其是在孕早期和孕中期发现的巨膀胱。进行了22例终止妊娠（47.8%），6例妊娠自然终止（13%）。18名婴儿存活，但2名在新生儿期死亡。最终，16名儿童存活（34.8%）。染色体异常很常见（22%）。
产前发现巨膀胱是一种复杂情况，胎儿预后通常较差。这需要多学科方法，以便让相关夫妇确定对此次妊娠的最佳护理方案。
