Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India.
J Ethnopharmacol. 2011 Jan 27;133(2):608-12. doi: 10.1016/j.jep.2010.10.045. Epub 2010 Oct 28.
ETHNO-PHARMACOLOGICAL RELEVANCE: The seeds of Sesamum indicum Linn. (Pedaliaceae) has been used traditionally for the treatment of wounds in Buldhana district of Maharashtra state. Sesamol is the main anti-oxidative constituent contained mainly in the processed sesame seed oil which has not been explored scientifically for its wound healing activity.
To investigate the influence of sesamol (SM) on wound repair, both in normal and dexamethasone (DM) delayed healing processes in albino rats.
Incision, excision and dead space wounds were inflicted on albino rats (180-220 g) of either sex, under ketamine anaesthesia. Group I served as control, group II received SM 50 mg/kg i.p., group III was treated with dexamethasone (DM) i.m. (0.17 mg/kg) and SM+DM was given to group IV. The tensile strength, wound contraction, hydroxyproline, lysyl oxidase and total RNA and DNA levels (in granulation tissue) were measured.
The tensile strength significantly (p<0.05) increased with SM at 471.40±14.66 g when compared to control at 300.60±9.16 g in normal and DM suppressed healing. No significant change was observed in duration of wound contraction and lysyl oxidase when compared to control at 2.98±0.10 mg. SM treated rats showed a significant (p<0.05) rise in hydroxyproline levels at 6.45±0.45 mg when compared to control at 1.75±0.20 mg.
These results indicate that sesamol could be a promising drug in normal as well as delayed wound healing processes.
研究芝麻素（SM）对正常和地塞米松（DM）延迟愈合过程中大鼠伤口愈合的影响。
在氯胺酮麻醉下，对 180-220g 雄性和雌性白化大鼠进行切口、切除和死腔伤口。第 I 组作为对照，第 II 组给予 SM 50mg/kg 腹腔注射，第 III 组给予地塞米松（DM）肌内注射（0.17mg/kg），第 IV 组给予 SM+DM。测量拉伸强度、伤口收缩、羟脯氨酸、赖氨酰氧化酶和总 RNA 和 DNA 水平（肉芽组织）。
与对照组（300.60±9.16g）相比，SM 组（471.40±14.66g）的拉伸强度显著增加（p<0.05），正常情况下 DM 抑制愈合。与对照组（2.98±0.10mg）相比，伤口收缩和赖氨酰氧化酶的持续时间没有明显变化。与对照组（1.75±0.20mg）相比，SM 处理的大鼠羟脯氨酸水平显著升高（p<0.05），达到 6.45±0.45mg。
这些结果表明，芝麻素可能是一种有前途的药物，可用于正常和延迟的伤口愈合过程。
