卡里曼他星/巴图霉素生物合成操纵子编码细菌靶标FabI的一种自身抗性异构体。
The kalimantacin/batumin biosynthesis operon encodes a self-resistance isoform of the FabI bacterial target.
作者信息
Mattheus Wesley, Masschelein Joleen, Gao Ling-Jie, Herdewijn Piet, Landuyt Bart, Volckaert Guido, Lavigne Rob
机构信息
Laboratory of Gene Technology, Katholieke Universiteit Leuven, Kasteelpark Arenberg 21 Box 2462, Leuven B-3001, Belgium.
出版信息
Chem Biol. 2010 Oct 29;17(10):1067-71. doi: 10.1016/j.chembiol.2010.07.015.
BatG is a trans-2-enoyl-ACP reductase, encoded in the kalimantacin/batumin (kal/bat) biosynthesis operon. It is not essential for the production of the kal/bat secondary metabolite. Instead, BatG is an isoform of FabI, conferring full resistance to target bacteria. It also complements FabI in its role in fatty acid biosynthesis. The identification of FabI as the antibacterial target is important to assess clinical potential of the kalimantacin/batumin antibiotics against Staphylococcus aureus.
BatG是一种反式-2-烯脂酰-ACP还原酶，由卡里曼他星/巴图明（kal/bat）生物合成操纵子编码。它对于kal/bat次级代谢产物的产生并非必不可少。相反，BatG是FabI的一种同工型，赋予对目标细菌的完全抗性。它还在脂肪酸生物合成中补充了FabI的作用。将FabI鉴定为抗菌靶点对于评估卡里曼他星/巴图明抗生素对金黄色葡萄球菌的临床潜力很重要。
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