Otolaryngology and Facial Plastic Surgery Associates, Fort Worth, Texas, USA.
Am J Otolaryngol. 2011 Nov-Dec;32(6):455-8. doi: 10.1016/j.amjoto.2010.08.006. Epub 2010 Oct 29.
The purpose of this study is to review our series of metastatic basal cell carcinomas of the head and neck.
A retrospective review was conducted for this study.
All cases of documented metastatic basal cell carcinomas arising from a primary within the head and neck region and presenting for treatment to one of the authors (Y.D.) were included in this review.
Nine patients were available for review. Five patients had extension to but not transgression of the base of skull. Sites for metastatic disease included 4 lungs and 5 parotid glands. All metastatic lesions were treated with surgical excision, and 6 also received postoperative radiation therapy. No patient deaths from disease have been noted at an average follow-up of 4.7 years (range, 3-8.5 years). No evidence of further metastatic disease has been noted in any of these patients on follow-up.
Metastatic basal cell carcinoma arising from a head and neck primary is a rare entity. However, initial involvement of the skull base and/or dura by a basal cell carcinoma appears to warrant a complete metastatic workup and metastatic surveillance. When metastatic disease is discovered, it appears to be well treated by surgical resection with/without adjunctive radiation therapy. We do not favor chemotherapy for resectable basal cell carcinomas.
本研究旨在回顾我们一系列发生于头颈部的转移性基底细胞癌。
本研究为回顾性研究。
本研究纳入了作者（Y.D.）治疗的所有源自头颈部原发性、出现转移的基底细胞癌病例。
9 名患者可供回顾。5 例患者的颅底有侵犯但未穿透。转移病灶部位包括 4 例肺部和 5 例腮腺。所有转移性病变均采用手术切除治疗，6 例患者术后还接受了放射治疗。在平均 4.7 年（3-8.5 年）的随访中，没有患者死于疾病。在这些患者的随访中，均未发现进一步的转移性疾病。
源自头颈部原发性的转移性基底细胞癌是一种罕见实体瘤。然而，基底细胞癌最初累及颅底和/或硬脑膜似乎需要进行全面的转移检查和转移监测。当发现转移性疾病时，手术切除联合/不联合辅助放射治疗似乎可以很好地治疗。我们不主张对可切除的基底细胞癌进行化疗。
