基于人群的队列研究（JPHC 研究）：丙型肝炎病毒载量对肝细胞癌发生率的影响。
Impact of viral load of hepatitis C on the incidence of hepatocellular carcinoma: A population-based cohort study (JPHC Study).
机构信息
National Cancer Center, Tokyo, Japan.
出版信息
Cancer Lett. 2011 Jan 28;300(2):173-9. doi: 10.1016/j.canlet.2010.10.002. Epub 2010 Oct 29.
Impact of viral load of HCV on the incidence of hepatocellular carcinoma was investigated using a population-based cohort consisting of 20,794 Japanese. A total of 114 newly arising cases of hepatocellular carcinoma were diagnosed during follow-up. Compared to the hepatitis virus-negative group, the hazard ratio (HR) of developing hepatocellular carcinoma was 35.8-fold higher in HCV monoinfection (95% confidence interval [CI], 20.7-62.7). A titer-dependent increase in risk was not identified. The risk was 3.86-fold higher (CI; 1.73-8.62) for genotype 1 than genotype 2. Our findings suggest that HCV viremia strongly influences the occurrence of hepatocellular carcinoma without titer-dependence.
本研究利用包含 20794 名日本人的基于人群的队列，调查了 HCV 病毒载量对肝细胞癌发生率的影响。在随访期间共诊断出 114 例新发肝细胞癌病例。与肝炎病毒阴性组相比，HCV 单一感染的肝癌发病风险比（HR）高 35.8 倍（95%置信区间 [CI]，20.7-62.7）。未发现与病毒载量相关的风险增加。与基因型 2 相比，基因型 1 的风险高 3.86 倍（CI；1.73-8.62）。我们的研究结果表明，HCV 病毒血症强烈影响肝细胞癌的发生，而与病毒载量无关。
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