Department of Biology, The University of Iowa, Iowa City, IA 52242, USA.
Trends Microbiol. 2011 Jan;19(1):8-13. doi: 10.1016/j.tim.2010.10.001. Epub 2010 Oct 29.
The evolution of new signal transductions pathways is poorly understood. Here I present a rare glimpse into the evolution of one such pathway, namely the white-cell pheromone response pathway in Candida albicans. In this pathway, the upper portion has been derived intact from the ancestral pathway for mating, the targeted transcription factor from an ancestral filamentation or biofilm pathway, and the upregulated genes from an ancestral biofilm pathway. Each component of this pathway, therefore, has been derived from a conserved pathway. I suggest that the evolution of this new pathway provides one possible paradigm for the evolution of other signal transduction pathways in new cell types.
新信号转导途径的进化还不太清楚。在这里，我将罕见地介绍一个这样的途径的进化，即白色念珠菌中的白细胞信息素反应途径。在这个途径中，上半部分完整地来源于交配的祖先途径，靶向转录因子来源于祖先的丝状或生物膜途径，上调的基因来源于祖先的生物膜途径。因此，这个途径的每个组成部分都来自于保守途径。我认为这个新途径的进化为新细胞类型中其他信号转导途径的进化提供了一个可能的范例。
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