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颅内动脉瘤破裂致蛛网膜下腔出血继发脑血管痉挛的尼莫地平治疗

[Management using nimodipine of cerebral vasospasm secondary to subarachnoid hemorrhage caused by rupture of an intracranial aneurysm].

作者信息

Maldonado J A, Milchorena G, López-Camacho O, Madrazo I

机构信息

Departamento de Neurocirugía, Hospital de Especialidades, Centro Médico La Raza, México.

出版信息

Arch Invest Med (Mex). 1990 Apr-Jun;21(2):179-87.

PMID:2103708
Abstract

The cerebral vasospasm secondary to subarachnoid hemorrhage due to the rupture of an intracranial aneurysm has a high morbidity/mortality. Its cause is still unknown, so we obtain controversial results after prevention and treatment. We studied two groups, of 29 patients each one, where the first was treated with systemic nimodipine, and the second was the control group. We did not observed any correlation between the clinic vasospasm or the symptomatic, and the radiographic one. There was no difference between the final results of both groups. No collateral effects were shown in other organs with the use of this agent.

摘要

颅内动脉瘤破裂导致蛛网膜下腔出血继发的脑血管痉挛具有较高的发病率/死亡率。其病因仍不清楚,因此我们在预防和治疗后得到了有争议的结果。我们研究了两组,每组29例患者,第一组用尼莫地平全身治疗,第二组为对照组。我们未观察到临床血管痉挛或症状性血管痉挛与影像学血管痉挛之间存在任何相关性。两组的最终结果没有差异。使用该药物未在其他器官显示出副作用。

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