ENT Department, Chania General Hospital, Chania, Crete, Greece.
Rhinology. 2010 Sep;48(3):331-8. doi: 10.4193/Rhino09.123.
To study the effect of functional endoscopic sinus surgery (FESS) in patients with chronic rhinosinusitis (CRS) and nasal polyps (NP) with concomitant asthma.
The study was designed to evaluate prospectively whether FESS can influence parameters of asthma in patients with CRS with nasal polyps.
One hundred thirty seven patients were recruited from the ENT-Allergy and Panedoscopy Clinic of the ENT Department. All selected patients underwent medical therapy for CRS and NP for 12 weeks, and in case of no improvement, they proceeded to surgical treatment. They also underwent pre- and post-treatment subjective and objective measurements for CRS and asthma. In the study, 86 patients were finally evaluated who completed the protocol and were followed up for a period of 12 months. The patients showed statistically significant improvement of the objective measurements for asthma, from baseline to six and twelve months follow-up. No significant increase was found in the proportion of patients with well or very well overall asthma-control during the follow-up period. There was a clear improvement in the use of bronchodilators, oral steroids and need for hospitalization for asthma.
Obviously, there is a link between CRS with NP and asthma. The data analysis of our study supports the hypothesis that FESS could have beneficial effect on both diseases improving objective and subjective measurements.
研究功能性内窥镜鼻窦手术（FESS）对伴有哮喘的慢性鼻-鼻窦炎（CRS）和鼻息肉（NP）患者的影响。
该研究旨在前瞻性评估 FESS 是否可以影响伴有鼻息肉的 CRS 患者的哮喘参数。
从耳鼻喉科耳鼻喉过敏和泛内镜诊所招募了 137 名患者。所有入选患者均接受了 12 周的 CRS 和 NP 的药物治疗，如果没有改善，则进行手术治疗。他们还接受了 CRS 和哮喘的术前和术后主观和客观测量。在这项研究中，最终评估了 86 名完成方案并随访了 12 个月的患者。患者的哮喘客观测量值从基线到 6 个月和 12 个月随访均有统计学显著改善。在随访期间，哮喘总体控制良好或非常好的患者比例没有明显增加。支气管扩张剂、口服类固醇和因哮喘住院的使用明显减少。
显然，CRS 伴 NP 与哮喘之间存在关联。我们的研究数据分析支持 FESS 可能对两种疾病都有有益影响的假设，改善客观和主观测量。
