适度运动不会加重二尖瓣脱垂所致二尖瓣反流的严重程度。

Moderate exercise does not increase the severity of mitral regurgitation due to mitral valve prolapse.

作者信息

Pecini Redi, Dalsgaard Morten, Møller Daniel V, Jensen Morten S, Kofoed Klaus F, Nielsen Walter, Nielsen Olav W, Høst Nis, Elming Hanne, Goetze Jens Peter, Hassager Christian, Køber Lars

机构信息

Cardiology Department, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark.

出版信息

Echocardiography. 2010 Oct;27(9):1031-7. doi: 10.1111/j.1540-8175.2010.01200.x.

DOI:10.1111/j.1540-8175.2010.01200.x

PMID:21039809

Abstract

BACKGROUND

Mitral regurgitation (MR) secondary to ischemic heart disease (IHD) increases during exercise. We tested the hypothesis that the same is also true for MR due to mitral valve prolapse (MVP).

METHODS

Consecutive patients with asymptomatic MR of varying severity underwent exercise test on a supine bicycle with workload up to a maximum of 100 W. Echocardiographic measurements were performed at rest and at peak exercise. The study was designed to detect an effective regurgitant orifice (ERO) change of at least 10 mm² during exercise.

RESULTS

Twenty-six patients (21 male, age 56 ± 12 years (mean ± SD)) were included. Patients had an ERO of 35 ± 23 mm² (mean ± SD) and regurgitation volume of 48 ± 38 mL (mean ± SD). In these patients, ERO remained unchanged (an increase of 2 ± 15 mm² during exercise, P = 0.6). The regurgitation volume (RVol) decreased with 11 ± 16 mL (mean ± SD), P = 0.003. When calculated for 1 minute, RVol increased during exercise (P = 0.01), but in relation to the total cardiac output it decreased significantly (P = 0.02).

CONCLUSION

Exercise does not increase the severity of MR due to MVP, in contrast to MR secondary to IHD. Different disease mechanisms behind these two types of MR could explain this difference.

摘要

背景

缺血性心脏病（IHD）继发的二尖瓣反流（MR）在运动时会增加。我们检验了二尖瓣脱垂（MVP）所致MR也存在同样情况的假设。

方法

连续纳入不同严重程度无症状MR患者，在仰卧位自行车上进行运动试验，工作量最大达100W。在静息和运动峰值时进行超声心动图测量。该研究旨在检测运动期间有效反流口面积（ERO）至少改变10mm²。

结果

纳入26例患者（21例男性，年龄56±12岁（均值±标准差））。患者ERO为35±23mm²（均值±标准差），反流容积为48±38mL（均值±标准差）。在这些患者中，ERO保持不变（运动期间增加2±15mm²，P=0.6）。反流容积（RVol）减少11±16mL（均值±标准差），P=0.003。按1分钟计算时，运动期间RVol增加（P=0.01），但相对于总心输出量则显著减少（P=0.02）。