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酒精灌洗在嵌甲苯酚化疗法中的疗效证据。

Evidence of the efficacy of alcohol lavage in the phenolization treatment of ingrown toenails.

机构信息

Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain.

出版信息

J Eur Acad Dermatol Venereol. 2011 Jul;25(7):794-8. doi: 10.1111/j.1468-3083.2010.03864.x. Epub 2010 Oct 6.

Abstract

BACKGROUND

For treatment of ingrown toenails, a phenolization is often chosen. Many reports describe an intra-operative irrigation or lavage of the wound with various types of alcohol to neutralize any residual phenol from this treatment. There are conflicting reports in the literature as to whether a true neutralization is required or merely effective removal of excess phenol.

OBJECTIVE

The aim of our study was to analyse the suitability and effectiveness of the alcohol lavage step during the treatment of ingrown toenails with a phenolization procedure.

METHODS

We performed an in vitro study using human skin and a diffusion cell apparatus to measure the amount of phenol remaining after various lavage washes. The effect of phenol evaporation was also examined.

RESULTS

There was no measurable amount of phenol collected after each experiment, suggesting that diffusion of phenol through the skin does not exist. The open compartment test had significantly less phenol recovered compared with the occluded compartment test, indicating phenol evaporation.

STUDY LIMITATIONS

None.

CONCLUSIONS

An alcohol lavage step after the phenolization procedure can be a suitable and effective means of diluting and removing any excess or residual phenol from the exposed area.

摘要

背景

对于嵌甲的治疗,常选择苯酚化疗法。许多报道描述了术中用各种类型的酒精冲洗或灌洗伤口,以中和这种治疗中残留的苯酚。文献中对于是否需要真正的中和,或者仅仅是有效去除多余的苯酚存在争议。

目的

我们的研究旨在分析在使用苯酚化疗法治疗嵌甲时,酒精冲洗步骤的适用性和有效性。

方法

我们使用人体皮肤和扩散细胞装置进行了一项体外研究,以测量在各种冲洗洗涤后残留的苯酚量。还检查了苯酚蒸发的影响。

结果

每次实验后都没有收集到可测量的苯酚量,这表明苯酚不会通过皮肤扩散。与封闭隔室测试相比,开放隔室测试回收的苯酚明显减少,表明苯酚蒸发。

研究局限性

无。

结论

在苯酚化疗法后进行酒精冲洗步骤,可以是一种合适且有效的方法,用于稀释和去除暴露区域的任何多余或残留的苯酚。

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