星形细胞瘤细胞涂片肿瘤血管的特征
Characteristics of tumour vessels in cytological squash smears of astrocytic tumours.
作者信息
Sato S, Sato Y, Marutsuka K, Takeshima H, Asada Y
机构信息
Department of Pathology, Faculty ofMedicine, University of Miyazaki, Kihara, Kiyotake, Miyazaki, Japan.
出版信息
Cytopathology. 2011 Oct;22(5):313-7. doi: 10.1111/j.1365-2303.2010.00807.x. Epub 2010 Oct 11.
OBJECTIVE
Smear preparations are useful tools from which to diagnose brain tumours intraoperatively. Although vascular proliferation is histologically a key feature of high-grade astrocytoma, the characteristics of tumour vessels in smear preparations have not been determined.
METHODS
We examined the density and morphological parameters (area, width, nuclear layer and branches of vessel wall) of tumour vessels in squash smears of 43 primary astrocytomas (grade II diffuse astrocytomas, n=9; grade III anaplastic astrocytomas, n=13; grade IV glioblastomas, n=21) and normal brain tissues (n=11).
RESULTS
Vessel density and all morphological parameters were significantly higher in grade IV than in the other grades of tumours and in normal brain tissue. Vessel area, width and nuclear layer were greater in grade III than in normal brain tissue. The sensitivity and specificity of these vessel parameters for astrocytomas were 75-100% and 82-100%, respectively.
CONCLUSIONS
Tumour vessel evaluations from squash smears provide useful information for the intraoperative diagnosis and grading of astrocytic tumours.
目的
涂片制备是术中诊断脑肿瘤的有用工具。尽管血管增生在组织学上是高级别星形细胞瘤的关键特征，但涂片制备中肿瘤血管的特征尚未明确。
方法
我们检测了43例原发性星形细胞瘤（II级弥漫性星形细胞瘤9例、III级间变性星形细胞瘤13例、IV级胶质母细胞瘤21例）和正常脑组织（11例）压片涂片中肿瘤血管的密度和形态学参数（面积、宽度、核层及血管壁分支）。
结果
IV级肿瘤的血管密度和所有形态学参数均显著高于其他级别肿瘤及正常脑组织。III级肿瘤的血管面积、宽度和核层大于正常脑组织。这些血管参数对星形细胞瘤的敏感性和特异性分别为75%-100%和82%-100%。
结论
压片涂片的肿瘤血管评估为星形细胞瘤的术中诊断及分级提供了有用信息。
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