Department of Dermatology, Chacha Nehru Bal Chikitsalaya, New Delhi, India.
Dermatol Surg. 2010 Dec;36(12):2030-6. doi: 10.1111/j.1524-4725.2010.01760.x. Epub 2010 Oct 11.
Infantile hemangiomas (IHs) are the most common benign tumors of infancy and may need to be treated in some cases. Oral corticosteroids are the mainstay of therapy but are not without their attendant side effects.
To evaluate the efficacy of combination therapy with oral corticosteroids and polidocanol sclerotherapy in hemangiomas needing treatment.
Eight children with IHs were started on oral prednisolone 3 to 4 mg/kg per day and fortnightly sclerotherapy with 3% polidocanol solution. The outcome was evaluated on the basis of color, turgidity of the lesion, ongoing growth, and assessment by parents and physician. Serial photographic records were maintained. The response was graded as excellent, good, poor, or nil. Complications were recorded.
Four male and four female patients presented at a mean age of 4.6 months. The average area of the lesions was 40.6 cm(2) . The mean duration of treatment with steroids at full dose was 8.2 weeks and mean total duration of treatment was 28.6 weeks. Mean number of sclerotherapy sessions required was 4.7. Complications included ischemic necrosis, rebound growth, and ulceration.
Combining oral corticosteroids with polidocanol sclerotherapy produced excellent results in the patients treated, with minimal attendant side effects.
婴儿血管瘤（IHs）是婴儿期最常见的良性肿瘤，在某些情况下需要治疗。口服皮质类固醇是治疗的主要方法，但也有其伴随的副作用。
评估口服皮质类固醇和聚多卡醇硬化疗法联合治疗需要治疗的血管瘤的疗效。
8 例婴儿血管瘤患者开始口服泼尼松龙 3 至 4mg/kg/天，每两周用 3%聚多卡醇溶液进行硬化治疗。根据颜色、病变的肿胀程度、持续生长以及家长和医生的评估来评估结果。保留连续的照片记录。反应分为优秀、良好、差或无。记录并发症。
4 名男性和 4 名女性患者平均年龄为 4.6 个月。病变的平均面积为 40.6cm2。口服皮质类固醇全剂量治疗的平均持续时间为 8.2 周，总治疗持续时间为 28.6 周。需要的硬化治疗次数平均为 4.7 次。并发症包括缺血性坏死、反弹生长和溃疡。
口服皮质类固醇与聚多卡醇硬化疗法联合治疗，在治疗患者时取得了极好的效果，副作用最小。
