Gloria-Bottini Fulvia, Nicotra Maria, Ianniello Francesca, Bottini Egidio
Division of Human Population Biopathology and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, School of Medicine, University of Rome Tor Vergata, Rome, Italy.
J Obstet Gynaecol Res. 2011 Jan;37(1):32-6. doi: 10.1111/j.1447-0756.2010.01306.x. Epub 2010 Oct 11.
FUT2 is an autosomal gene that controls the secretion of the ABH blood group antigens in organic fluids. The secretor gene plays an important role during intrauterine life. The aim of this study is to investigate a possible association between the ABH system and reproductive success in couples with primary repeated spontaneous abortion (RSA).
MATERIAL & METHOD: Sixty-six couples with primary repeated spontaneous abortion and 356 consecutive healthy puerperae with their newborn infants from the white population of Rome were studied. All couples were seen at the Center for Reproductive Disorders of the Institute of Obstetrics and Gynecology of the University of Rome, La Sapienza. Secretor phenotype was determined by saliva in all subjects by laboratory standard procedures.
In couples with primary RSA, the frequency of non-secretor phenotype of both husbands and wives (37.9%) were significantly higher than those of newborns from other couples (21.4% for male newborns and 29.4% for female newborns). In husbands, but not in wives, of the couples with primary RSA succeeding in having at least a live born infant after 5 years of follow up, the frequency of non-secretor phenotype was significantly lower than those without a liveborn infant (22.8% vs 54.8%). The presence of joint secretor phenotype in both husband and wife was positively associated with having a liveborn infant after 5 years of follow up (odds ratio = 4.57, 95% C.I.1.39-15.6).
Secretor phenotype of couples with RSA, especially of the husband, could facilitate 'reproductive success'.
FUT2是一种常染色体基因，可控制有机体液中ABH血型抗原的分泌。分泌型基因在子宫内生命过程中起着重要作用。本研究的目的是调查ABH系统与原发性反复自然流产（RSA）夫妇生殖成功之间可能存在的关联。
对来自罗马白人人群的66对原发性反复自然流产夫妇以及356名连续健康产妇及其新生儿进行了研究。所有夫妇均在罗马第一大学妇产科研究所生殖障碍中心就诊。通过实验室标准程序，采用唾液测定所有受试者的分泌型表型。
在原发性RSA夫妇中，丈夫和妻子的非分泌型表型频率（37.9%）显著高于其他夫妇的新生儿（男婴为21.4%，女婴为29.4%）。在随访5年后至少生育一名活产婴儿的原发性RSA夫妇中，丈夫（而非妻子）的非分泌型表型频率显著低于未生育活产婴儿的夫妇（22.8%对54.8%）。丈夫和妻子均为联合分泌型表型与随访5年后生育活产婴儿呈正相关（优势比=4.57，95%可信区间1.39 - 15.6）。
RSA夫妇，尤其是丈夫的分泌型表型可能有助于“生殖成功”。
