Department of Psychiatry, Hospital Universitari Vall d'Hebron, Passeig Vall d'Hebron 119-129, Barcelona, Catalonia, Spain.
Genes Brain Behav. 2011 Mar;10(2):149-57. doi: 10.1111/j.1601-183X.2010.00649.x. Epub 2010 Nov 4.
Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable developmental disorder characterized by a persistent impairing pattern of inattention and/or hyperactivity-impulsivity. Using families from a genetic isolate, the Paisa population from Colombia, and five independent datasets from four different populations (United States, Germany, Norway and Spain), a highly consistent association was recently reported between ADHD and the latrophilin 3 (LPHN3) gene, a brain-specific member of the LPHN subfamily of G-protein-coupled receptors that is expressed in ADHD-related regions, such as amygdala, caudate nucleus, cerebellum and cerebral cortex. To replicate the association between LPHN3 and ADHD in adults, we undertook a case-control association study in 334 adult patients with ADHD and 334 controls with 43 single nucleotide polymorphisms (SNPs) covering the LPNH3 gene. Single- and multiple-marker analyses showed additional evidence of association between LPHN3 and combined type ADHD in adulthood [P = 0.0019; df = 1; odds ratio (OR) = 1.82 (1.25-2.70) and P = 5.1e-05; df = 1; OR = 2.25 (1.52-3.34), respectively]. These results further support the LPHN3 contribution to combined type ADHD, and specifically to the persistent form of the disorder, and point at this new neuronal pathway as a common susceptibility factor for ADHD throughout the lifespan.
注意力缺陷多动障碍（ADHD）是一种常见的、高度遗传性发育障碍，其特征是持续性的注意力不集中和/或多动冲动模式。使用来自遗传隔离的 Paisa 人群（哥伦比亚的一个群体）以及来自四个不同人群（美国、德国、挪威和西班牙）的五个独立数据集，最近报道了 ADHD 与 latrophilin 3（LPHN3）基因之间存在高度一致的关联，LPHN3 是一种大脑特异性 G 蛋白偶联受体 LPHN 亚家族成员，在与 ADHD 相关的区域（如杏仁核、尾状核、小脑和大脑皮层）中表达。为了在成人中复制 LPHN3 与 ADHD 之间的关联，我们对 334 名成年 ADHD 患者和 334 名对照进行了病例对照关联研究，使用 43 个单核苷酸多态性（SNP）覆盖 LPNH3 基因。单标记和多标记分析显示，LPHN3 与成年期混合性 ADHD 之间存在额外的关联证据[P = 0.0019；df = 1；优势比（OR）= 1.82（1.25-2.70）和 P = 5.1e-05；df = 1；OR = 2.25（1.52-3.34）]。这些结果进一步支持了 LPHN3 对混合性 ADHD 的贡献，特别是对该疾病持续性形式的贡献，并指出这条新的神经元途径是 ADHD 整个生命周期的常见易感因素。
