Department of Physiology, University of Szeged, Faculty of Medicine, Szeged National Psychiatry Center, Balassa u. 6, Budapest, Hungary.
Genes Brain Behav. 2011 Mar;10(2):223-7. doi: 10.1111/j.1601-183X.2010.00657.x. Epub 2010 Nov 9.
ZNF804A, encoding the transcription factor zinc-finger protein 804A, is a genome-wide supported psychosis gene associated with schizophrenia and bipolar disorder. However, only little information is available on the role of ZNF804A regarding the cognitive phenotype of psychosis. In this study, we investigated the relationship between the single-nucleotide polymorphism rs1344706 (A/C, A = risk allele) in ZNF804A and attention in 200 healthy volunteers. We used the attention network test, which was designed to separate the three main components of attention (alerting, orienting and executive control). Results showed a significant association with the executive control network: the A/A genotype and the A-allele were associated with increased reaction time when conflicting information was present. In contrast, rs1344706 was not related to alerting and orienting. These results suggest that the genome-wide supported psychosis risk variant of ZNF804A is associated with altered executive control (larger conflict effect), which is a potential endophenotype of psychotic disorders.
锌指蛋白 804A（ZNF804A）编码转录因子，是全基因组支持的与精神分裂症和双相情感障碍相关的精神病基因。然而，关于 ZNF804A 与精神病认知表型的关系，仅有少量信息。在这项研究中，我们调查了 ZNF804A 中单核苷酸多态性 rs1344706（A/C，A=风险等位基因）与 200 名健康志愿者注意力之间的关系。我们使用了注意力网络测试，该测试旨在分离注意力的三个主要成分（警觉、定向和执行控制）。结果显示与执行控制网络有显著关联：在存在冲突信息时，A/A 基因型和 A 等位基因与反应时间延长有关。相反，rs1344706 与警觉和定向无关。这些结果表明，ZNF804A 的全基因组支持的精神病风险变异与执行控制改变（更大的冲突效应）有关，这是精神障碍的一个潜在内表型。
