Respiratory Medicine Department, University of Thessaly School of Medicine, University Hospital of Larissa, 41110, Greece.
Respir Res. 2010 Oct 31;11(1):152. doi: 10.1186/1465-9921-11-152.
Since its cloning in 1994, leptin has emerged in the literature as a pleiotropic hormone whose actions extend from immune system homeostasis to reproduction and angiogenesis. Recent investigations have identified the lung as a leptin responsive and producing organ, while extensive research has been published concerning the role of leptin in the respiratory system. Animal studies have provided evidence indicating that leptin is a stimulant of ventilation, whereas researchers have proposed an important role for leptin in lung maturation and development. Studies further suggest a significant impact of leptin on specific respiratory diseases, including obstructive sleep apnoea-hypopnoea syndrome, asthma, COPD and lung cancer. However, as new investigations are under way, the picture is becoming more complex. The scope of this review is to decode the existing data concerning the actions of leptin in the lung and provide a detailed description of leptin's involvement in the most common disorders of the respiratory system.
自 1994 年克隆以来，瘦素在文献中被认为是一种具有多种功能的激素，其作用范围从免疫系统稳态到生殖和血管生成。最近的研究已经确定了肺是瘦素反应和产生的器官，而关于瘦素在呼吸系统中的作用已经发表了大量研究。动物研究提供了证据表明瘦素是通气的刺激物，而研究人员提出了瘦素在肺成熟和发育中的重要作用。研究进一步表明，瘦素对特定的呼吸系统疾病有重大影响，包括阻塞性睡眠呼吸暂停低通气综合征、哮喘、COPD 和肺癌。然而，随着新的研究正在进行，情况变得更加复杂。本综述的目的是解读关于瘦素在肺中的作用的现有数据，并详细描述瘦素在呼吸系统最常见疾病中的参与。
