Terzidis Agapios, Sergentanis Theodoros N, Antonopoulos George, Syrigos Constantinos, Efremidis Anna, Polyzos Aristidis, Dessypris Nick, Petridou Eleni T
Department of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School, Athens, Greece.
Oncology. 2009;76(1):19-25. doi: 10.1159/000177952. Epub 2008 Nov 24.
Leptin is intimately intertwined in the molecular pathophysiology of several cancer types; with regard to lung cancer, however, limited research has been conducted, with overall conflicting results.
The present case-control study comprises 66 non-small-cell lung cancer (NSCLC) cases and 132 healthy controls matched for gender and age. Lifestyle, sociodemographic and medical history information has been obtained in addition to body mass index (BMI) measurements and weight change during the last 2 months. Serum leptin and adiponectin levels were determined following a standard protocol.
In multiple logistic regression analyses, elevated serum leptin emerged as a risk factor for NSCLC independent of central obesity, more pronounced after controlling for BMI and recent weight loss (odds ratio = 4.58, 95% confidence interval: 1.94-10.82). Additionally, smoking and animal foods consumption were strongly associated with the disease, whereas plant foods consumption showed a protective association.
The observed higher serum leptin levels in NSCLC cases might be attributed to direct or indirect effects mediated by cancer- or cachexia-related cytokines. In line with the growth-promoting properties of leptin in the lung tissue documented elsewhere, increased serum leptin concentration may represent a tumor-promoting event during non-small-cell lung carcinogenesis.
瘦素与多种癌症类型的分子病理生理学密切相关；然而，关于肺癌的研究有限，且结果总体相互矛盾。
本病例对照研究包括66例非小细胞肺癌（NSCLC）患者和132例年龄及性别匹配的健康对照者。除了测量体重指数（BMI）和过去2个月内的体重变化外，还收集了生活方式、社会人口统计学和病史信息。血清瘦素和脂联素水平按照标准方案测定。
在多项逻辑回归分析中，血清瘦素升高是NSCLC的一个危险因素，独立于中心性肥胖，在控制BMI和近期体重减轻后更为明显（比值比 = 4.58，95%置信区间：1.94 - 10.82）。此外，吸烟和食用动物性食物与该疾病密切相关，而食用植物性食物则显示出保护作用。
NSCLC患者中观察到的较高血清瘦素水平可能归因于癌症或恶病质相关细胞因子介导的直接或间接作用。与其他地方记录的瘦素在肺组织中的促生长特性一致，血清瘦素浓度升高可能代表非小细胞肺癌发生过程中的一个促肿瘤事件。
