van Hirtum Pauline V, Prins Mandy, ten Oever Jaap, Nijziel Marten R, Vreugdenhil Gerard, Dercksen M Wouter
Universiteit Maastricht, faculteit Health, Medicine and Life Sciences, the Netherlands.
Ned Tijdschr Geneeskd. 2010;154:A2112.
Sweet syndrome, also known as acute febrile neutrophilic dermatosis, was diagnosed in two patients. Patient A, a 68-year-old man, had had chronic lymphatic leukaemia for four years, with a recent relapse. Patient B, a 58-year-old man, had been diagnosed with renal cell carcinoma four years earlier. Both patients presented with general discomfort, high fever, neutrophilic leukocytosis and diffuse, non-tender maculopapular exanthema, partly blanching on applied pressure, and vesicles spread over the body. Patient A had clinical signs of a septic shock. In both patients, histological examination confirmed clinical suspicion of Sweet syndrome and both had a good response on prednisone. In patient B, progression of renal cell carcinoma was found more than a half year later. It is important to recognise the varied clinical picture of the rare disorder that is Sweet syndrome because it can lead to severe clinical illness, especially in patients with an underlying malignancy.
两名患者被诊断出患有Sweet综合征，又称急性发热性嗜中性皮病。患者A为一名68岁男性，患慢性淋巴细胞白血病四年，近期复发。患者B为一名58岁男性，四年前被诊断出患有肾细胞癌。两名患者均出现全身不适、高热、嗜中性白细胞增多以及弥漫性、无压痛的斑丘疹，部分皮疹受压后褪色，且水疱遍布全身。患者A有感染性休克的临床体征。两名患者的组织学检查均证实了对Sweet综合征的临床怀疑，且两人对泼尼松均有良好反应。患者B在半年多后发现肾细胞癌进展。认识到Sweet综合征这种罕见疾病的多样临床表现很重要，因为它可导致严重的临床疾病，尤其是在有潜在恶性肿瘤的患者中。
