Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA.
Cell Stem Cell. 2010 Nov 5;7(5):553-4. doi: 10.1016/j.stem.2010.10.004.
Skeletal remodeling requires recruitment of osteoblast precursors, in the form of MSCs, to the bone surface. In this issue of Cell Stem Cell, Wu et al. (2010) demonstrate that this event is mediated by osteoclastic mobilization of active transforming growth factor β1, which is inhibited by a common antiosteoporosis drug.
骨骼重塑需要招募成骨细胞前体（以间充质干细胞的形式）到骨表面。在本期《细胞—干细胞》杂志中，Wu 等人（2010）证明了这一事件是由破骨细胞动员活性转化生长因子β1 介导的，而这一过程被一种常见的抗骨质疏松药物所抑制。
