设计一类新型联苯 CETP 抑制剂。
Design of a novel class of biphenyl CETP inhibitors.
机构信息
Department of Medicinal Chemistry, Merck Sharp & Dohme Corp., Rahway, NJ 07065, USA.
出版信息
Bioorg Med Chem Lett. 2010 Dec 15;20(24):7469-72. doi: 10.1016/j.bmcl.2010.10.019. Epub 2010 Oct 15.
PMID:21041082
Abstract
A new class of CETP inhibitors was designed and prepared. These compounds are potent both in vitro and in vivo. The most active compound (12d) has shown an ability to raise HDL significantly in transgenic mouse PD model.
摘要
设计并制备了一类新型的 CETP 抑制剂。这些化合物在体外和体内均具有很强的活性。最活跃的化合物（12d）在转基因 PD 模型小鼠中显示出显著升高 HDL 的能力。
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