由 2-糠醛和 3,3'-二氨基联苯缩合得到的希夫碱配体的合成及光谱研究，L 及其与 Co(II)、Ni(II)、Cu(II)和 Zn(II)的配合物：L 及其 Cu(II)和 Zn(II)配合物的比较 DNA 结合研究。
Synthesis and spectroscopic studies on the Schiff base ligand derived from condensation of 2-furaldehyde and 3,3'-diaminobenzidene, L and its complexes with Co(II), Ni(II), Cu(II) and Zn(II): comparative DNA binding studies of L and its Cu(II) and Zn(II) complexes.
机构信息
Division of Inorganic Chemistry, Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2011 Jan;78(1):29-35. doi: 10.1016/j.saa.2010.02.034. Epub 2010 Apr 20.
The Schiff base ligand, N,N'-bis-(2-furancarboxaldimine)-3,3'-diaminobenzidene (L) obtained by condensation of 2-furaldehyde and 3,3'-diaminobenzidene, was used to synthesize the mononuclear complexes of the type, M(L)2 [M=Co(II), Ni(II), Cu(II) and Zn(II)]. The newly synthesized ligand, (L) and its complexes have been characterized on the basis of the results of the elemental analysis, molar conductance, magnetic susceptibility measurements and spectroscopic studies viz, FT-IR, 1H and 13C NMR, mass, UV-vis and EPR. EPR, UV-vis and magnetic moment data revealed a square planar geometry for the complexes with distortion in Cu(II) complex and conductivity data show a 1:2 electrolytic nature of the complexes. Absorption and fluorescence spectroscopic studies support that Schiff base ligand, L and its Cu(II) and Zn(II) complex exhibit significant binding to calf thymus DNA. The highest binding affinity in case of L may be due to the more open structure as compared to the metal coordinated complexes.
席夫碱配体 N,N'-双-(2-呋喃甲酰亚胺)-3,3'-二氨基联苯（L）是由 2-糠醛和 3,3'-二氨基联苯缩合得到的，用于合成单核配合物，类型为[M（L）]（NO3）2 [M=Co（II），Ni（II），Cu（II）和 Zn（II）]。新合成的配体（L）及其配合物的性质是根据元素分析、摩尔电导率、磁性测量和光谱研究的结果来确定的，包括 FT-IR、1H 和 13C NMR、质谱、UV-vis 和 EPR。EPR、UV-vis 和磁矩数据表明配合物具有正方形平面几何构型，但 Cu(II)配合物存在扭曲，电导率数据表明配合物具有 1:2 的电解性质。吸收和荧光光谱研究表明，席夫碱配体 L 及其 Cu(II)和 Zn(II)配合物与小牛胸腺 DNA 具有显著的结合作用。L 的结合亲和力最高可能是由于其与金属配位的配合物相比具有更开放的结构。
Zotero 插件