L-亮氨酸和乙二醛希夫碱配合物的合成、光谱表征及与 DNA 的比较结合研究。
Synthesis, spectroscopic characterization and comparative DNA binding studies of Schiff base complexes derived from L-leucine and glyoxal.
机构信息
Division of Inorganic Chemistry, Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2011 Nov;82(1):31-6. doi: 10.1016/j.saa.2011.06.035. Epub 2011 Jun 23.
The mononuclear Schiff base complexes of the type, [ML(CH(3)OH)(2)] [M = Co(II), Ni(II), Cu(II) and Zn(II)] have been synthesized by template condensation of L-leucine and glyoxal. The complexes have been characterized on the basis of the results of the elemental analysis, molar conductance, magnetic susceptibility measurements and spectroscopic studies viz, FT-IR, Mass, (1)H NMR and (13)C NMR spectra. The UV-vis and magnetic moment data revealed an octahedral geometry around Co(II), Ni(II) ion with distortion around Cu(II) ion complex confirmed by EPR data. The conductivity data show a non-electrolytic nature of the complexes. Absorption and fluorescence spectroscopic studies support that all the complexes exhibit a significant binding to calf thymus DNA.
单核希夫碱配合物的类型，[ML（CH（3）OH）（2）] [M = Co（II），Ni（II），Cu（II）和 Zn（II）] 已通过模板缩合 L-亮氨酸和乙二醛合成。根据元素分析、摩尔电导率、磁化率测量和光谱研究的结果，对配合物进行了表征，即 FT-IR、质谱、（1）H NMR 和（13）C NMR 光谱。紫外可见和磁矩数据表明 Co（II）、Ni（II）离子周围具有八面体几何形状，Cu（II）离子配合物的 EPR 数据证实了这种扭曲。电导率数据表明配合物具有非电解质性质。吸收和荧光光谱研究表明，所有配合物都与小牛胸腺 DNA 具有显著的结合能力。
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