疼痛是什么？
What is this thing called pain?
机构信息
Department of Neurology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
J Clin Invest. 2010 Nov;120(11):3742-4. doi: 10.1172/JCI45178. Epub 2010 Nov 1.
Abstract
To paraphrase Cole Porter's famous 1926 song, "What is this thing called pain? This funny thing called pain, just who can solve its mystery?" Pain, like love, is all consuming: when you have it, not much else matters, and there is nothing you can do about it. Unlike love, however, we are actually beginning to tease apart the mystery of pain. The substantial progress made over the last decade in revealing the genes, molecules, cells, and circuits that determine the sensation of pain offers new opportunities to manage it, as revealed in this Review series by some of the foremost experts in the field.
摘要
用科尔·波特（Cole Porter）1926 年著名歌曲中的话来说，“这叫做疼痛的东西是什么？这种叫做疼痛的有趣东西，谁能解开它的奥秘？”疼痛就像爱情一样，是一种全神贯注的体验：当你有了它，其他的事情都不重要了，而且你对此无能为力。然而，与爱情不同的是，我们实际上已经开始逐渐揭开疼痛之谜。在过去十年中，揭示决定疼痛感觉的基因、分子、细胞和回路的实质性进展为我们提供了新的机会来管理疼痛，正如该领域一些权威专家在本综述系列中所揭示的那样。
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本文引用的文献
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Central modulation of pain.疼痛的中枢调节。
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Labeled lines meet and talk: population coding of somatic sensations.标记线交汇并交流：躯体感觉的群体编码。
J Clin Invest. 2010 Nov;120(11):3773-8. doi: 10.1172/JCI43426. Epub 2010 Nov 1.
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Nociceptors: the sensors of the pain pathway.伤害感受器：疼痛通路的传感器。
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The discovery and development of analgesics: new mechanisms, new modalities.镇痛药的发现和发展：新机制，新形式。
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Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1.多种慢性疼痛状态与 KCNS1 中的一个常见氨基酸变异等位基因有关。
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Spinal alpha 2-adrenoceptor-mediated analgesia in neuropathic pain reflects brain-derived nerve growth factor and changes in spinal cholinergic neuronal function.脊髓 α2-肾上腺素能受体介导的神经病理性疼痛的镇痛作用反映了脑源性神经营养因子和脊髓胆碱能神经元功能的变化。
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