Department of Gastroenterology, School of Medicine, Ankara University, Ankara, Turkey.
Digestion. 2011;83(1-2):83-8. doi: 10.1159/000320379. Epub 2010 Oct 30.
Golgi protein 73 (GP73) expressions have been detected in hepatocellular carcinoma (HCC) and bile duct carcinoma.
Our purpose was to determine the serum levels of GP73 in patients with HCC and to compare them with α-fetoprotein (AFP) levels.
Seventy-five patients with HCC, 55 patients with cirrhosis and 28 healthy controls were included.
The median serum GP73 levels were 0.27 ng/ml (range = 0.078-4.95) in controls, 0.32 ng/ml (range = 0.078-39.63) in cirrhotics and 0.21 ng/ml (range = 0.053-4.98) in those with HCC. The median serum AFP levels were 1.37 ng/ml (range = 0.61-6.89) in controls, 2.32 ng/ml (range = 0.61-85.24) in cirrhotics and 50.65 ng/ml (range = 0.8-37,642) in HCC patients (p < 0.0001 for HCC vs. controls and cirrhotics). The sensitivity, specificity, and positive and negative predictive values of GP73 were 82, 9, 55 and 27%, respectively. Whereas the levels were 68, 94, 94 and 70%, respectively, for AFP(13) and 60, 98, 97 and 64% for AFP(20), respectively. There was no correlation between GP73 levels and other prognostic parameters including tumor size, tumor type, Child-Pugh classification, TNM staging, Cancer of the Liver Italian Program score, portal vein thrombosis and extrahepatic metastasis.
GP73 has a lower diagnostic and prognostic value for HCC. AFP is superior to GP73 for diagnosis of early HCC.
高尔基蛋白 73（GP73）的表达已在肝细胞癌（HCC）和胆管癌中被检测到。
本研究旨在测定 HCC 患者血清 GP73 水平，并与甲胎蛋白（AFP）水平进行比较。
纳入 75 例 HCC 患者、55 例肝硬化患者和 28 名健康对照者。
对照组、肝硬化组和 HCC 组患者的中位血清 GP73 水平分别为 0.27ng/ml（范围=0.078-4.95）、0.32ng/ml（范围=0.078-39.63）和 0.21ng/ml（范围=0.053-4.98）。对照组、肝硬化组和 HCC 组患者的中位血清 AFP 水平分别为 1.37ng/ml（范围=0.61-6.89）、2.32ng/ml（范围=0.61-85.24）和 50.65ng/ml（范围=0.8-37,642）（p<0.0001，HCC 组与对照组和肝硬化组比较）。GP73 的敏感性、特异性、阳性预测值和阴性预测值分别为 82%、9%、55%和 27%。而 AFP（13）的水平分别为 68%、94%、94%和 70%，AFP（20）的水平分别为 60%、98%、97%和 64%。GP73 水平与肿瘤大小、肿瘤类型、Child-Pugh 分级、TNM 分期、意大利肝癌计划评分、门静脉血栓形成和肝外转移等其他预后参数之间无相关性。
GP73 对 HCC 的诊断和预后价值较低。AFP 对早期 HCC 的诊断优于 GP73。
