肿瘤坏死因子血清水平在器官移植中的意义。
The significance of tumour necrosis factor serum levels in organ transplantation.
作者信息
White D J, Obers A
机构信息
Department of Surgery, University of Cambridge, Addenbrooke's Hospital, United Kingdom.
出版信息
Eur Cytokine Netw. 1990 Oct-Nov;1(4):245-9.
This paper describes a detailed study of tumour necrosis factor release during the immediate post transplant period in recipients of liver and kidney allografts. The results show no correlation between levels of TNF and rejection in Azathioprine and steroid treated patients and give good correlation in cyclosporin A immunosuppressed patients. Treatment with monoclonal antibody Campath 1-G caused high levels of TNF production. Interleukin-1 levels were not associated with levels of TNF. Sequential measurements of TNF levels may provide an aid to early diagnosis of graft rejection.
本文描述了对肝和肾同种异体移植受者移植后即刻期肿瘤坏死因子释放情况的详细研究。结果显示，在接受硫唑嘌呤和类固醇治疗的患者中，肿瘤坏死因子水平与排斥反应之间无相关性，而在接受环孢素A免疫抑制治疗的患者中则具有良好的相关性。用单克隆抗体Campath 1-G治疗会导致高水平的肿瘤坏死因子产生。白细胞介素-1水平与肿瘤坏死因子水平无关。对肿瘤坏死因子水平进行连续测量可能有助于移植排斥反应的早期诊断。
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