Remya Ks, Beena P, Bijesh Pv, Sheeba A
Nazareth College of Pharmacy, Othera P.O, Thiruvalla, Pathanamthitta (Dist.), Kerala - 689 546, India.
J Young Pharm. 2010 Jul;2(3):234-9. doi: 10.4103/0975-1483.66794.
The present work was aimed at formulation development, evaluation and comparative study of the effects of superdisintegrants in Cefixime 50 mg oral disintegrating tablets. The superdisintegrants used for the present study were sodium starch glycolate and crosscarmellose sodium. The formulated tablets were evaluated for various tableting properties, like hardness, thickness, friability, weight variation, disintegration time and dissolution rate. Comparative evaluation of the above-mentioned parameters established the superiority of the tablets formulated with crosscarmellose sodium to those formulated with sodium starch glycolate.
本研究旨在开发头孢克肟50mg口腔崩解片的处方，评估超级崩解剂的效果并进行对比研究。本研究中使用的超级崩解剂为羟丙甲纤维素和交联羧甲基纤维素钠。对制得的片剂进行了多种压片性能评估，如硬度、厚度、脆碎度、重量差异、崩解时间和溶出速率。对上述参数的对比评估证实，用交联羧甲基纤维素钠制得的片剂优于用羟丙甲纤维素制得的片剂。
