Division of General Paediatrics, Medical University of Graz, Department of Pediatrics, Auenbruggerplatz 30, 8036 Graz, Austria.
Hamostaseologie. 2010 Nov;30 Suppl 1:S168-71.
Increasing evidence indicates that thrombin plays a role not only in thrombosis but also in the progression of atherosclerosis.
The relationship between thrombin generation and intima-media thickness (IMT) as an index of subclinical atherosclerosis was investigated. Participants, material, methods: We examined 163 asymptomatic middle-aged persons free of overt clinical atherosclerotic disease. They underwent ultrasonography of the common carotid arteries. In addition, thrombin generation was measured by means of CAT (calibrated automated thrombography). For our study we divided the healthy study participants into three age groups (<45, 45-60 and >60 years).
A significant positive correlation was seen between endogenous thrombin potential (ETP) (p = 0.012), time to peak (TTP) (p = 0.033) start tail (p = 0.007) and carotid IMT in the group of healthy volunteers younger than 45 years.
We demonstrated that in adults younger than 45 years without clinically overt atherosclerotic disease ETP was significantly associated with carotid IMT. It is tempting to speculate that ETP may serve as an index for subclinical atherosclerosis in persons below 45 years.
越来越多的证据表明，凝血酶不仅在血栓形成中起作用，而且在动脉粥样硬化的进展中起作用。
研究凝血酶生成与内膜中层厚度（IMT）作为亚临床动脉粥样硬化指标之间的关系。
参与者、材料和方法：我们检查了 163 名无症状的中年人群，他们没有明显的临床动脉粥样硬化疾病。他们接受了颈总动脉超声检查。此外，通过 CAT（校准自动血栓生成）测量凝血酶生成。为了我们的研究，我们将健康的研究参与者分为三组（<45 岁、45-60 岁和>60 岁）。
在年龄小于 45 岁的健康志愿者组中，内源性凝血酶潜能（ETP）（p = 0.012）、达峰时间（TTP）（p = 0.033）起始尾（p = 0.007）与颈动脉 IMT 之间存在显著正相关。
我们证明，在没有临床明显动脉粥样硬化疾病的 45 岁以下成年人中，ETP 与颈动脉 IMT 显著相关。ETP 可能作为 45 岁以下人群亚临床动脉粥样硬化的指标，这令人不禁产生遐想。
