Laboratory for Evolution and Development, Biochemistry Department, University of Otago, Dunedin, New Zealand.
Dev Genes Evol. 2010 Dec;220(7-8):179-90. doi: 10.1007/s00427-010-0340-6. Epub 2010 Nov 3.
Notch signaling has been implicated in the segmentation of vertebrates but is not involved in segmentation in Drosophila. Recent evidence, however, implies that Notch signaling regulates segmentation in some Arthropods, including an insect, and that Notch signaling regulated segmentation in the common ancestor of Vertebrates and Arthropods. Notch signaling regulates clock-like formation of segments in both groups, a phenomenon not seen in Drosophila. We present evidence that Notch signaling components are expressed in a pattern implying a role in segmentation in honeybees, where the expression of genes involved in segmentation are modulated in a temporal way. Despite this, pharmacological investigation and RNA interference experiments indicate that Notch signaling does not regulate segmentation in honeybees, but instead regulates patterning within segments after segmentation itself has occurred. Notch signaling thus does not regulate segmentation in holometabolous insects, even when segments appear to form in anterior-posterior sequence.
Notch 信号通路在脊椎动物的体节形成中发挥作用，但在果蝇中不参与体节形成。然而，最近的证据表明 Notch 信号通路在某些节肢动物（包括昆虫）中调节体节形成，并且 Notch 信号通路在脊椎动物和节肢动物的共同祖先中调节体节形成。Notch 信号通路调节两组的节段状时钟形成，而在果蝇中未观察到这种现象。我们提供的证据表明，Notch 信号通路的组成部分以一种暗示在分割中的作用的模式表达在蜜蜂中，其中参与分割的基因的表达以时间方式进行调节。尽管如此，药理学研究和 RNA 干扰实验表明，Notch 信号通路并不调节蜜蜂的分割，而是在分割本身发生后调节分割内的模式形成。因此， Notch 信号通路不调节完全变态昆虫的分割，即使节段似乎按前后顺序形成。
