Galoyan Armen
HKh Buniatian Institute of Biochemistry, NAS RA, 5/1 Sevak Str, Yerevan 0014, Armenia.
Neurochem Res. 2010 Dec;35(12):2001-17. doi: 10.1007/s11064-010-0306-0. Epub 2010 Nov 3.
Discovery of neurosecretion of cardioactive neurohormones produced by hypothalamic nuclei (NSO and NPV), as well as the biosynthesis of several immunomodulators (signal molecules of the neuroendocrine immune system of brain), deciphering of their chemical structure and study of their biological properties led to the foundation of two important trends of neurobiology: neuroendocrine immunology and cardiology. Hormone formation by atrium ganglionary nerve cells and auriculum establishment of neurohumoral interactions between hypothalamic and atrium neurosecretion indicated the existence of the system neuroendocrine hypothalamus--endocrine heart. Study of their biological properties promoted creation of powerful neurohormonal preparations for the treatment of immune, cardio-vascular, neurodegenerative, infectious and tumor diseases. Concepts suggested by us on neuroendocrine cardiology and immunology, create large perspectives for development of the theory and its implementation in medicine.
下丘脑核（NSO和NPV）产生的具有心脏活性的神经激素的神经分泌的发现，以及几种免疫调节剂（脑的神经内分泌免疫系统的信号分子）的生物合成，其化学结构的破译及其生物学特性的研究导致了神经生物学的两个重要趋势的建立：神经内分泌免疫学和心脏病学。心房神经节神经细胞形成激素以及下丘脑与心房神经分泌之间建立神经体液相互作用，表明存在神经内分泌下丘脑 - 内分泌心脏系统。对其生物学特性的研究促进了用于治疗免疫、心血管、神经退行性、感染性和肿瘤疾病的强大神经激素制剂的创建。我们提出的关于神经内分泌心脏病学和免疫学的概念，为该理论的发展及其在医学中的应用创造了广阔的前景。
