肠道微粒体药物代谢。大鼠和豚鼠酶的比较，以及大鼠隐窝和绒毛尖端细胞酶的比较。
Intestinal microsomal drug metabolism. A comparison of rat and guinea-pig enzymes, and of rat crypt and villous tip cell enzymes.
机构信息
Robens Institute of Industrial and Environmental Health and Safety, Department of Biochemistry, University of Surrey, Guildford, Surrey GU2 5XH, UK.
出版信息
Biochem Pharmacol. 1981 Sep 1;30(17):2415-20. doi: 10.1016/0006-2952(81)90335-x.
A comparison was made of the properties of microsomes prepared from the small intestines of guinea pigs and rats. The NADPH2 cytochrome c reductase activity and cytochrome b5 and cytochrome P-450 content in rat microsomes was 42, 47 and 64% of that in the guinea pig, ethoxycoumarin deethylase activity was comparable, while arylesterase activity was twice as active in rats as guinea pigs. Investigation of the distribution of these and other parameters in rat intestinal epithelia revealed a preferential location of cytochrome P-450 in the villous tip while other parameters showed a more similar distribution between microsomes prepared from the villous tip and crypt.
比较了从小肠制备的豚鼠和大鼠微粒体的性质。大鼠微粒体中的 NADPH2 细胞色素 c 还原酶活性、细胞色素 b5 和细胞色素 P-450 含量分别为豚鼠的 42%、47%和 64%，乙氧基香豆素脱乙基酶活性相当，而芳酯酶活性则是豚鼠的两倍。这些和其他参数在大鼠肠上皮中的分布研究表明，细胞色素 P-450 优先位于绒毛尖端，而其他参数在绒毛尖端和隐窝制备的微粒体之间的分布更为相似。
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