Clement R P, Tofilon P J, Piper W N
Nutr Cancer. 1981;3(2):63-71. doi: 10.1080/01635588109513703.
The relationship between folate deficiency, heme content, and microsomal drug metabolism in the intestinal mucosa of the guinea pig was examined. Weanling male guinea pigs were pair-fed a folate-deficient diet, and intestinal mucosal folate levels were measured. A significant decrease (75%) in these levels was observed at 3 weeks after diet initiation. A significant decrease (78%) in intestinal mucosal drug metabolism (7-ethoxycoumarin O-deethylase activity) and a significant decrease (46%) in intestinal mucosal heme content were also observed at this time. These findings indicate that folic acid deficiency in the guinea pig results in a marked reduction in heme content and microsomal drug metabolism of the intestinal mucosa.
研究了豚鼠肠黏膜中叶酸缺乏、血红素含量与微粒体药物代谢之间的关系。将断乳雄性豚鼠成对饲养在叶酸缺乏的饮食中，并测量肠黏膜叶酸水平。在开始饮食3周后，观察到这些水平显著下降（75%）。此时还观察到肠黏膜药物代谢（7-乙氧基香豆素O-脱乙基酶活性）显著下降（78%）以及肠黏膜血红素含量显著下降（46%）。这些发现表明，豚鼠体内叶酸缺乏会导致肠黏膜血红素含量和微粒体药物代谢显著降低。
