Kumar M Vijay, Sambaia K, Ramesh B N, Manohar B, Lokesh B R
Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore 570013.
J Indian Med Assoc. 2010 Mar;108(3):156, 158-60.
Several epidemiological studies have established that Indians have a higher incidence of coronary heart disease. Because of vast differences in ethnicity, food habits and sociocultural background of Indians, it is essential that survey be conducted for profiling risk factor indicators in subjects from different parts of the country with adequate sample size. This study was carried out on CFTRI employees whose population is originally drawn from different parts of the country with diverse food habits. The population consisting of 624 subjects (514 men and 110 women) were subjected to general health check-up, blood and urine analysis under the supervision of a medical officer. Sixty-one individuals (9.77%) were found to be diabetic and 73 individuals (11.69%) were hypertensive of which 11.7% were also found to have diabetes. The mean serum cholesterol concentration in men was found to be 158 mg % and that in women was 165 mg %. Ratio of total cholesterol to HDL-cholesterol was found to be greater than 6.5 in all the cases. Blood group analysis indicated that 41.5% of the subjects belonged to O(+) group (n = 259) followed by B(+) 25.6% (n = 160), A(+) 24.6% (n = 154) and AB(+) 4.48% (n = 28). Twenty-three individuals were Rh-negative. It was observed that serum cholesterol and triglycerides were lower in O(+) groups, compared to individuals in other groups. The incidence of diabetes and hypertension in O(+) was 5.79% and 10.4%, B(+)12.5% and 15.6%, A(+) 11.0% and 12.3% and AB(+) 21.4% and 7.1% respectively. Eight individuals were found to have myocardial infarction. Among them four belonged to A(+), two to B(+) and one each to AB(+)and O(+).
多项流行病学研究证实，印度人冠心病的发病率较高。由于印度人在种族、饮食习惯和社会文化背景方面存在巨大差异，因此有必要对来自该国不同地区且样本量充足的受试者进行调查，以分析风险因素指标。本研究以中央食品技术研究所以及印度食品公司（CFTRI）的员工为对象，这些员工最初来自该国不同地区，饮食习惯各异。624名受试者（514名男性和110名女性）在一名医务人员的监督下接受了全面的健康检查、血液和尿液分析。发现61人（9.77%）患有糖尿病，73人（11.69%）患有高血压，其中11.7%的人同时患有糖尿病。男性的平均血清胆固醇浓度为158毫克%，女性为165毫克%。在所有病例中，总胆固醇与高密度脂蛋白胆固醇的比值均大于6.5。血型分析表明，41.5%的受试者属于O(+)组（n = 259），其次是B(+)组，占25.6%（n = 160），A(+)组占24.6%（n = 154），AB(+)组占4.48%（n = 28）。23人Rh阴性。观察发现，与其他组的个体相比，O(+)组的血清胆固醇和甘油三酯水平较低。O(+)组糖尿病和高血压的发病率分别为5.79%和10.4%，B(+)组为12.5%和15.6%，A(+)组为11.0%和12.3%，AB(+)组为21.4%和7.1%。发现8人患有心肌梗死。其中4人属于A(+)组，2人属于B(+)组，AB(+)组和O(+)组各1人。
