Department of Chemistry, Washington University, St. Louis, Missouri 63130, United States.
J Am Chem Soc. 2010 Nov 24;132(46):16610-6. doi: 10.1021/ja107490t. Epub 2010 Nov 2.
Site-selective Pd(0)-catalyzed reactions have been developed to functionalize a microelectrode array. Heck, Suzuki, and allylation reactions have all been accomplished. The reactions are compatible with both 1K and 12K arrays and work best when a nonsugar porous reaction layer is used. Suzuki reactions are faster than the Heck reactions and thus require more careful control of the reactions in order to maintain confinement. The allylation reaction requires a different confining agent than the Heck and Suzuki reactions but can be accomplished nicely with quinone as an oxidant for Pd(0).
已经开发出了选择性的 Pd(0)催化反应,用于功能化微电极阵列。已经完成了 Heck、Suzuki 和烯丙基化反应。这些反应与 1K 和 12K 阵列都兼容,并且在使用非糖多孔反应层时效果最佳。Suzuki 反应比 Heck 反应更快,因此需要更仔细地控制反应以保持限制。烯丙基化反应需要与 Heck 和 Suzuki 反应不同的限制剂,但可以使用醌作为 Pd(0)的氧化剂来很好地完成。