贝赫切特葡萄膜炎患者接受英夫利昔单抗治疗后视盘新生血管消退。
Regression of optic disc neovascularization in patients with Behçet's uveoretinitis after infliximab therapy.
机构信息
Department of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
出版信息
J Ocul Pharmacol Ther. 2010 Dec;26(6):627-30. doi: 10.1089/jop.2010.0031. Epub 2010 Nov 2.
PURPOSE
Optic disc neovascularization (NVD) in patients with Behçet's uveoretinitis is a relatively uncommon but severe complication that lacks standardized treatments. We report 2 cases of Behçet's uveoretinitis that achieved partial regression of NVD after infliximab therapy.
METHODS
Intravenous infliximab infusions were administrated to 2 immunosuppressive therapy-resistant Behçet's uveoretinitis patients with severe NVD accompanied by vitreous hemorrhage (both eyes in case 1 and the left eye in case 2 ). Best-corrected visual acuity, funduscopic findings, and fluorescein angiography were evaluated before and after the treatments.
RESULTS
After being switched to infliximab therapy, NVD in both cases stopped developing and regressed partially, as confirmed by fluorescein angiography and resolution of vitreous hemorrhage, which led to an improvement of the best-corrected visual acuity.
CONCLUSIONS
Results suggest that infliximab administration might be an effective treatment in NVD patients with Behçet's uveoretinitis.
目的
贝赫切特葡萄膜炎患者的视盘新生血管（NVD）是一种相对罕见但严重的并发症，缺乏标准化的治疗方法。我们报告了 2 例贝赫切特葡萄膜炎患者，他们在接受英夫利昔单抗治疗后 NVD 部分消退。
方法
对 2 例伴有玻璃体积血的严重 NVD 的免疫抑制治疗抵抗的贝赫切特葡萄膜炎患者（1 例双眼，2 例左眼）给予静脉注射英夫利昔单抗。在治疗前后评估最佳矫正视力、眼底检查和荧光素血管造影。
结果
在转为英夫利昔单抗治疗后，2 例患者的 NVD 停止发展并部分消退，荧光素血管造影和玻璃体积血的消退证实了这一点，这导致最佳矫正视力的改善。
结论
结果表明，英夫利昔单抗治疗可能是治疗贝赫切特葡萄膜炎伴 NVD 患者的有效方法。
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