Atherosclerosis Research Group (ASF) Vienna, Schwarzpanierstr 17, 1090, Vienna, Austria.
Platelets. 1991;2(1):41-3. doi: 10.3109/09537109109005501.
Calcium channel blockers are known to inhibit platelet aggregation in vitro and ex vivo. We studied the influence of a single oral dose of diltiazem (60 mg), nifedipine (10 mg) and verapamil (80 mg) on ADP-, collagen-, and epinephrine-induced platelet aggregation, malondialdehyde formation, serum thromboxane B(2) and platelet sensitivity to PGI(2) in 24 patients with coronary artery disease. Ninety minutes after drug intake most platelet function parameters were clearly decreased. Only collagen-stimulated platelet aggregation showed no significant drug effect. Malondialdehyde formation was more affected than ADP-induced platelet aggregation. Platelet sensitivity to PGI(2) was enhanced after nifedipine. These results suggest an alteration of the prostaglandin system as one of the underlying mechanisms. Diltiazem seems to be the most effective drug with a potent influence on platelet function ex vivo.
钙通道阻滞剂已知可抑制体外和离体血小板聚集。我们研究了单次口服剂量的地尔硫卓（60 毫克）、硝苯地平（10 毫克）和维拉帕米（80 毫克）对 24 例冠心病患者 ADP、胶原和肾上腺素诱导的血小板聚集、丙二醛形成、血清血栓素 B2 和血小板对 PGI2 敏感性的影响。药物摄入 90 分钟后，大多数血小板功能参数明显降低。只有胶原刺激的血小板聚集没有显示出明显的药物作用。丙二醛的形成比 ADP 诱导的血小板聚集受影响更大。硝苯地平可增强血小板对 PGI2 的敏感性。这些结果表明，前列腺素系统的改变是其潜在机制之一。地尔硫卓似乎是最有效的药物，对体外血小板功能有很强的影响。
