Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, 118 83 Stockholm, Sweden.
Clin Sci (Lond). 2011 Mar;120(5):179-81. doi: 10.1042/CS20100521.
Saturated fatty acids are toxic to pancreatic β-cells. By inducing apoptosis, they contribute to a decrease in β-cell mass, a hallmark of Type 2 diabetes. In the present issue of Clinical Science, Keane and co-workers show that the polyunsaturated fatty acid arachidonic acid protects the β-cell against the toxic effects of palmitate. As Type 2 diabetes is characterized by subclinical inflammation, and arachidonic acid and metabolites thereof are produced during states of inflammation, it is possible that pancreatic β-cells use arachidonic acid as a compound for self-protection.
饱和脂肪酸对胰腺β细胞有毒性。通过诱导细胞凋亡，它们导致β细胞数量减少，这是 2 型糖尿病的一个标志。在本期的《临床科学》杂志中，基恩及其同事表明，多不饱和脂肪酸花生四烯酸可保护β细胞免受软脂酸的毒性影响。由于 2 型糖尿病的特点是亚临床炎症，并且在炎症状态下会产生花生四烯酸及其代谢产物，因此胰腺β细胞可能将花生四烯酸用作自身保护的化合物。
