Schools of Health Professions, Medicine, and Dentistry, Birmingham, AL 35294-1270, USA.
Clin Exp Rheumatol. 2010 Sep-Oct;28(5 Suppl 61):S102-9. Epub 2010 Oct 28.
Methotrexate (MTX), an antifolate, is an anchor drug for the treatment of rheumatoid arthritis (RA). Both folic acid (FA) and folinic acid (FLN) supplements have been shown to reduce the toxicity of MTX when used in RA therapy. The effect of folate supplementation on MTX efficacy still needs to be studied. FA supplementation has been found to have a beneficial effect on homocysteine (hcy) metabolism and may prevent the formation of the less effective metabolite 7-hydroxy-MTX. The cost of FA supplements is substantially less than the cost of FLN supplements. This article reviews clinical trials related to folate supplementation during MTX therapy for RA.
甲氨蝶呤（MTX）是一种抗叶酸药物，是治疗类风湿关节炎（RA）的基础药物。叶酸（FA）和亚叶酸（FLN）补充剂在 RA 治疗中已被证明可降低 MTX 的毒性。叶酸补充对 MTX 疗效的影响仍需研究。FA 补充已被发现对同型半胱氨酸（hcy）代谢有益，可能预防形成效果较差的代谢物 7-羟基-MTX。FA 补充剂的成本明显低于 FLN 补充剂。本文综述了 MTX 治疗 RA 期间叶酸补充的临床试验。
